博士畢業(yè)于中南大學(xué)湘雅醫(yī)學(xué)院,介入心臟病學(xué)專業(yè),畢業(yè)后先后至北京安貞醫(yī)院、南方醫(yī)科大學(xué)、暨南大學(xué)附屬第一醫(yī)院等工作,2015年至法國(guó)巴黎Henri Mondor醫(yī)院心血管中心訪問(wèn)學(xué)者,專注于左心耳封堵和TAVI等技術(shù)的學(xué)習(xí)。
學(xué)術(shù)任職
中國(guó)生物醫(yī)學(xué)工程學(xué)會(huì)心臟康復(fù)分會(huì)委員,廣東省胸部疾病醫(yī)師分會(huì)常務(wù)委員,廣東省醫(yī)學(xué)會(huì)心電生理與起搏分會(huì)青年委員、委員,廣東省醫(yī)師協(xié)會(huì)心電生理分會(huì)委員,廣東省醫(yī)學(xué)會(huì)心血管介入分會(huì)委員,廣東省中西醫(yī)結(jié)合學(xué)會(huì)心血管介入分會(huì)委員。
主研方向
干細(xì)胞衰老與動(dòng)脈粥樣硬化、炎癥與缺血心肌血管新生、糖尿病心肌病發(fā)病機(jī)制等。
主要課題
1.國(guó)家自然科學(xué)基金青年基金項(xiàng)目低氧誘導(dǎo)因子1a相關(guān)microRNA調(diào)控內(nèi)皮祖細(xì)胞旁分泌和血管新生相關(guān)機(jī)制研究。
2.廣東省自然科學(xué)基金面上項(xiàng)目殘粒脂蛋白經(jīng)由M2巨噬細(xì)胞調(diào)控冠脈側(cè)枝循環(huán)形成機(jī)制研究。
3.廣東省自然科學(xué)基金面上項(xiàng)目紅細(xì)胞膜膽固醇參與冠脈慢血流或無(wú)復(fù)流相關(guān)機(jī)制研究。
4.國(guó)家自然科學(xué)基金面上項(xiàng)目 殘粒脂蛋白促進(jìn)內(nèi)皮祖細(xì)胞衰老的micro RNAs調(diào)控機(jī)制探討。
5.國(guó)家自然科學(xué)基金主任基金,microRNA在VSEL-SCs分化成心肌細(xì)胞中的作用機(jī)制研究。
6.廣東省醫(yī)學(xué)科研基金項(xiàng)目,HIF-Notch介導(dǎo)的巨噬細(xì)胞與內(nèi)皮祖細(xì)胞交互作用加速缺血心肌血管新生機(jī)制研究。
獲獎(jiǎng)情況
獲得湖南省優(yōu)秀博士畢業(yè)生
2009年湖南醫(yī)學(xué)科技進(jìn)步一等獎(jiǎng)
2013年獲得廣東省團(tuán)委援疆優(yōu)秀隊(duì)員
2020年暨南大學(xué)附屬第一醫(yī)院“金刀獎(jiǎng)”
學(xué)術(shù)論著
主要SCI論文:
1. Yang DG(楊德光),Liu L,Zheng XY. Cyclin-dependent kinase inhibitor p16INK4a and telomerase may comodulate endothelial progenitor cells senecence. Review Ageing Res Rev. 20087:137-146.
2. Liu L Wen T Zheng XY Yang DG(楊德光) et al. Remnant-like particles accelerate endothelial progenitor cells senescence and induce cellular dysfunction via an oxidative mechanism.Atherosclerosis. 2009 Feb;202(2):405-14.
3. Zheng XY,Liu L,Yang DG(楊德光). Interaction between remnant-like lipoprotein particles and adipocytes.Int J Cardiol. 2009 Mar 20;133(1):3-7.
4. Yang DG (楊德光) Liu L Zhou SH et al. Remnant-like lipoproteins may accelerate endothelial progenitor cells senescence through inhibiting telomerase activity via the reactive oxygen species-dependent pathway . Canadian Journal of Cardiology. 27 (2011) 628–634.
5. Yang DG (楊德光) Liu L Zhou SH et al. MicroRNA profile in senescent endothelial progenitor cells induced by remnant-like lipoproteins. Chin Med J (Engl). 2012 Oct;125(19):3479-84. IF=0.901
6. Yang DG(楊德光)Wang JH Xiao M Shi X Zhou T. Role of Mir-155 in controlling Hif-1a level and promoting endothelial cells maturation. Sci Rep.20166:35316.
7. Jinhong Wang Li ZhangYing Tang Deguang Yang(楊德光). Lung Cancer Cells Positively Regulate PD-1 Level in Infiltrating CD8+ T Cells through PGE2/EP2 and PGE2/EP4 Pathways. Oncol Lett. 2018 Jan;15(1):552-558.
8. Shen A Hou X Yang D(楊德光) Liu T Zheng D Deng L Zhou T*. Role of osteoprotegerin and its gene polymorphisms in the occurrence of left ventricular hypertrophy in essential hypertensive patients. Medicine (Baltimore). 2014 Dec,93(29):e154.
9. Sui Z Shi Y Gao Z Yang D(楊德光,共同通訊作者) Wang Z. Expression of programmed cell death1 in T follicular helper cells is regulated by prostaglandin E2 secreted by HBV-infected HepG2.2.1.5 cells. Mol Med Rep. 2017 Jun;15(6):4305-4311.
10. Xiaofang Chen Tao Zhou Deguang Yang Jinyang Lu.Association Between ABCB1 Gene Polymorphism and Renal Function in Patients with Hypertension: A Case-Control Study. Med Sci Monit. 2017 Aug 9;23:3854-3860.
11. Dong Dong Deguang Yang(楊德光,共同第一作者) Luomin Lin Shuai Wang Baojian Wu. Circadian rhythm in pharmacokinetics and its relevance to chronotherapy. Biochem Pharmacology. 2020 May 22;178:114045. doi: 10.1016/j.bcp.2020.114045.
12. Lihui Tan Xiang Zhou Keke Wu Deguang Yang(楊德光,共同通訊作者) Yanpeng Jiao ChangrenZhou. Tannic acid/CaII anchored on the surface of chitin nanofiber sponge by layer-by-layer deposition: Integrating effective antibacterial and hemostatic performance. International Journal of Biological Macromolecules159:304-315.
13. Lianxia Guo Tianpeng Zhang Fei Wang Xun Chen Haiman Xu Cui Zhou Min Chen Fangjun Yu Shuai Wang Deguang Yang(共同通訊作者) Baojian Wu. Targeted inhibition of Rev-erbα/β limits ferroptosis to ameliorate folic acid-induced acute kidney injury. Br J Pharmacol. 2021 Jan;178(2):328-345.
14. Liu C Yang D Wang H(共同第一) Hu S Xie X Zhang L Jia H Qi Q. MicroRNA-197-3p mediates damage to human coronary artery endothelial cells via targeting TIMP3 in Kawasaki disease. Mol Cell Biochem. 2021 Aug 5. doi: 10.1007/s11010-021-04238-7. Online ahead of print.
醫(yī)生 | 所屬科室 | 時(shí)間段 |
楊德光 | 心血管內(nèi)科 | |
上午 (08:00~12:00)
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下午 (14:30~17:30)
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